Health Technology/clinical-trials

Adaptive RCT Opens: Personalised Internet-Delivered Transdiagnostic Therapy for Anxiety and Depression — Response-Based Treatment Optimisation

247 Health News Editorial

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12 June 2026

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4 min read

·clinical-trials

New adaptive RCT investigates personalised internet-delivered therapy for anxiety and depression, using early treatment response to guide intervention intensity. 366 participants will receive response-based treatment allocation.

Originally reported by ClinicalTrials.gov

References

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  2. 2.Barlow, D. H., Farchione, T. J., Bullis, J. R., Gallagher, M. W., Murray-Latin, H., Sauer-Zavala, S., Bentley, K. H., Boettcher, H. T., Cassiello-Robbins, C., Conklin, L. R., Chopra, S., & Ametaj, A. (2017). The unified protocol for transdiagnostic treatment of emotional disorders compared with diagnosis-specific protocols for anxiety disorders: A randomized clinical trial. JAMA Psychiatry, 74(9), 875-884. https://doi.org/10.1001/jamapsychiatry.2017.2164
  3. 3.Carlbring, P., Andersson, G., Cuijpers, P., Riper, H., & Hedman-Lagerlöf, E. (2018). Internet-based vs. face-to-face cognitive behavior therapy for psychiatric and somatic disorders: an updated systematic review and meta-analysis. Cognitive Behaviour Therapy, 47(1), 1-18. https://doi.org/10.1080/16506073.2017.1401115
  4. 4.Evans, C., Connell, J., Barkham, M., Margison, F., McGrath, G., Mellor-Clark, J., & Audin, K. (2002). Towards a standardised brief outcome measure: psychometric properties and utility of the CORE-OM. British Journal of Psychiatry, 180(1), 51-60. https://doi.org/10.1192/bjp.180.1.51
  5. 5.Kessler, R. C., Sampson, N. A., Berglund, P., Gruber, M. J., Al-Hamzawi, A., Andrade, L., Bunting, B., Demyttenaere, K., Florescu, S., de Girolamo, G., Gureje, O., He, Y., Hu, C., Huang, Y., Karam, E., Kovess-Masfety, V., Lee, S., Levinson, D., Medina Mora, M. E., ... Wilcox, M. A. (2015). Anxious and non-anxious major depressive disorder in the World Health Organization World Mental Health Surveys. Epidemiology and Psychiatric Sciences, 24(3), 210-226. https://doi.org/10.1017/S2045796015000189
  6. 6.Newby, J. M., McKinnon, A., Kuyken, W., Gilbody, S., & Dalgleish, T. (2015). Systematic review and meta-analysis of transdiagnostic psychological treatments for anxiety and depressive disorders in adulthood. Clinical Psychology Review, 40, 91-110. https://doi.org/10.1016/j.cpr.2015.06.002
  7. 7.Norman, S. B., Cissell, S. H., Means-Christensen, A. J., & Stein, M. B. (2006). Development and validation of an Overall Anxiety Severity And Impairment Scale (OASIS). Depression and Anxiety, 23(4), 245-249. https://doi.org/10.1002/da.20182
  8. 8.Universitat Jaume I. (2024). Efficacy of a Personalized, Response-based Transdiagnostic Intervention for Emotional Disorders Delivered Via the Internet: A Protocol for an Adaptive Randomized Controlled Trial. ClinicalTrials.gov. NCT07051148. https://clinicaltrials.gov/study/NCT07051148
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247 Health News Editorial

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